By Jeanne A. Rungby. Specialist. Drawing by Lars Bo Appel
Is it true that the spike protein from the mRNA vaccine has toxic properties?
German professor of human biology Ulrike Kämmerer has recently prepared a comprehensive report on Comirnaty, Pfizer's commercial Covid-19 vaccine, which most Danes have received.
The report contains a lot of important information, based on solid documentation in the form of scientific data. I will try to explain in plain language – to the best of my ability – what the report says about the spike protein from the mRNA vaccine (Comirnaty).
The report also addresses the content of LNP-wrapped DNA, mRNA, SV40, and the properties of lipid nanoparticles (LNP), which may become topics for later blogs.
This blog discusses the properties of the spike protein common to both the vaccine and the Covid-19 virus, as described in the report by Professor Ulrike Kämmerer.
The spike protein is the protein that sits on the surface of the virus (Wuhan 1) and also the protein that mRNA from the vaccine codes for once it has entered the body's cells. There is a small difference, namely two amino acids (2 proline) on the vaccine spike, which have no significant functional significance according to the report.
The spike protein is curled, like a garland, but if it is pulled out into a long string, it will appear like an old-fashioned cassette tape that has been cut and pasted, composed of parts from many different viruses and snake venoms.
The following is my understanding of the information in the report.
Structural and functional properties of the spike protein :
The spike protein is a large glycoprotein that has unique properties, including a highly efficient furin cleavage site that separates it into two subunits, S1 and S2 (subunit). The furin cleavage site is unique and enhances the virus's ability to infect cells by promoting spread and interaction.
The high level of cloning strongly suggests that the spike protein was developed in a laboratory.
The two parts, S1 and S2, have different properties. S1 contains receptor binding sites and S2 remains on the cell surface, where it facilitates membrane fusion, i.e. fusion of the cell walls into giant cells with many nuclei. These giant cells naturally lose their normal function. These are mainly immune cells.
The S1 subunit :
Circulates in the bloodstream after cleavage (at the furin cleavage site) and then binds to several receptors, including ACE2 (lock and key), which can potentially damage organ functions.
Contains a heparin binding site (key), which can affect the blood's ability to clot.
Exhibits similarities to neurotoxic peptides (small proteins, toxic to nerve cells) and prions, which can cause serious disorders of the nervous system.
The S2 subunit :
Causes cell membrane fusion, leading to the formation of syncytia (fused giant cells) that disrupt cell function. Syncytia are typically seen in the placenta and skeletal muscle, but as part of SARS-CoV-2 infections, especially in the lungs.
The spike protein alone can induce syncytia (fusion), even in uninfected normal cells, as shown in experiments from the Paul-Ehrlich-Institute in 2021. In this regard, it is important to know that PEI was responsible for the quality control of these products for the entire EU. PEI knew very early on that the spike protein was harmful because it could form fusions of cells. The S2 subunit can thus - like rings in water - damage healthy neighboring cells. This property is difficult to neutralize, even with specific antibodies, which suggests a significant risk with these genetic vaccines that trigger the production of the spike protein.
Syncytia formation can contribute to immunodeficiency by damaging or fusing lymphocytes, which are cells of the immune system, which no longer function.
Prescription binding sites (keys)
The spike protein has built-in multiple receptor binding sites, i.e. "keys" that fit corresponding locks on the surfaces of the body's various cells, which allows the protein to penetrate and trigger various biochemical mechanisms, including an overreaction in the immune system (Cytokine storm).
The more different “keys” a virus can use to anchor and penetrate the cell, the more tissue types (and organs) the virus can infect and multiply in.
The spike protein has an unnaturally large number of receptors "clipped together" from many different viruses in addition to coronavirus: The following 3 receptors are dominant:
· The ACE2 key fits receptors in the testicles, ovaries, lungs, intestines, kidneys, pancreas and blood vessels, which themselves are found in all organs including the heart.
· The KREMEN1 key originates from enteroviruses with key to hormone-producing glands, internal organs, muscle cells, brain and bone marrow.
· The ASGR1 key originates from the hepatitis (liver inflammation) C virus with a key to liver cells.
Thus, using these keys, the spike protein is extremely efficiently designed to penetrate all the cells of the body. The keys are associated with damage to blood vessels, blood clots, access to the brain via the blood-brain barrier, where it can cause inflammation (encephalitis, brain inflammation).
Nerve toxins and superantigens
Some of the parts on the “cassette tape” bear a strong resemblance to snake venom. Specifically, these parts come very close:
1. The venom of the Indian cobra ( Naja naja ) and the monocled cobra ( Naja kaouthia )
2. The venom of the Chinese multi-colored krait snake ( Bungarus multicinctus) .
3. The toxin from rabies, g-protein, where the virus enters nerve cells.
4. Entry keys, also called neuropilin receptors (NRP1 and NRP2)
5. A heparin key, which binds heparin sulfate and thereby affects the blood's ability to clot.
The spike protein has binding partners (key in lock) at the blood-brain barrier and on neurons (nerve cells), contributing to brain damage mechanisms, including blood clots and nerve cell inflammation.
The S1 subunit of the spike protein in particular has been linked to neuroinflammatory reactions, i.e. the immune system's attack on its own nerve cells, which could potentially contribute to conditions such as ME/CFS (Myalgic Encephalitis/Chronic Fatigue Syndrome) and increase the risk of neurological symptoms. In addition, the spike protein's effect on endothelial cells (blood vessel wall cells) can lead to blood vessel damage, ruptures, blood clots and similar complications.
Prion-like sequences :
A sequence in the spike protein of 38 amino acids, which is found in both the vector vaccine (including AstraZeneca's vaccine) and in the mRNA vaccines against Wuhan1 and the delta variant (not in the Omicron variant), has been compared to prions. Prions are proteins that have folded inappropriately and can cause other proteins in the vicinity to do the same. Prions are very difficult to break down in the body.
Prions are associated with neurodegenerative diseases. Cases of Creutzfeldt-Jakob disease have been reported following vaccination, but the exact effect of this sequence in humans is still under investigation.
HIV-like sequences.
Structural similarities have been found between the SARS-CoV-2 spike protein and the HIV-1 virus gp120 and Gag proteins. The late Luc Montagnier, the Nobel Prize winner who discovered HIV, pointed out that certain segments of the SARS-CoV-2 spike protein mimic significant parts of HIV gp120, located at important receptor binding sites (key sites).
Three specific regions in the spike protein (red, orange, and yellow in Pradhan's model) closely correspond to elements in HIV's gp120, suggesting a structural entity that may play a role in how the virus binds to host cells.
Drawing of Pradhan's model:
Summary of the properties of the spike protein:
Furin cleavage : Allows the S1 subunit to detach from the cells and circulate in the blood throughout the body.
Binding and distribution : S1 binds to blood vessel cells and other cells in various organs, including crossing the blood-brain barrier, which can lead to organ damage after covid-19 ("Long Covid") and post-vaccination ("Post Vac").
Evidence from staining shows S1 in small blood vessels in placentas from vaccinated pregnant women, indicating potential transmission to the fetus.
Long-term presence : S1 has been detected in macrophages, which are the immune system's scavenger cells, up to 15 months after infection without ongoing viral replication, suggesting that the protein may be either long-lasting or possibly produced independently of the virus in the body. The vaccination status of these individuals was not reported in the study. This highlights the widespread and potentially long-lasting presence of the S1 subunit in the body, which may have health implications.
Blood clots : The S1 fragment activates platelets, binds heparin, and causes inflammation of the vessel wall, leading to blood clots in the small blood vessels.
Lipid nanoparticles from vaccines distribute spike proteins throughout the body and trigger damage, especially to blood vessels and the formation of giant cells.
Damage to nerve cells : The S1 subunit crosses the blood-brain barrier and triggers encephalitis (brain inflammation) and potentially chronic fatigue syndrome (ME/CSF), contributing to neurological symptoms such as fatigue and cognitive problems.
Immune system disruption : Genetic vaccinations can lead to suppression of the immune system and increase susceptibility to infections such as shingles and cold pneumonia due to altered immunity and persistent circulation of spike protein.
Increased risk of Covid-19 with vaccinations : Data indicates a paradoxical increase in Covid-19 risk with multiple vaccine doses, suggesting a weakening of the immune system.
Cleveland Clinic study findings:
Data from the Cleveland Clinic study shows that there is a clear association between receiving genetic vaccinations and an increased cumulative risk of contracting Covid-19. Specifically, the study showed that the more vaccine doses a person received, the higher their susceptibility to Covid-19. See figure below.
A brand new study from Japan (2), which is not mentioned in the report, has just confirmed this observation, as the risk of getting Covid-19 increased by 63% with 1 – 2 doses, 104% with 3 – 4 doses and 121% with 5 – 7 doses.
The Cleveland study is also confirmed by other scientific studies. In particular, a study from the Netherlands supports this observation and shows a correlation between the number of vaccinations, mainly with Comirnaty, and an increase in subsequent SARS-CoV-2 infections (see the Comirnaty Facts report).
Does the Spike protein come from a laboratory?
According to author Ulrike Kämmerer “There is so much cloning within this type of spike protein (see also a very comprehensive analysis here : www.stopgof.com ) that it is far beyond natural origin. In addition, the virus has additional typical cloning signatures in other genes, so it is like a clear passport: I was born in a laboratory.... Fortunately, coronaviridae are not that dangerous and share a large pattern of cross-reactive proteins, so before 2020 almost 50% of the population was already immune to this virus via cross-reactive T cells.”
The report's general conclusions for Comirnaty:
Immune system disruption : The mRNA vaccine (Comirnaty) primarily targets dendritic cells (star-shaped immune cells), not muscle cells as one might think. This targeting leads to the expression of the full spike protein on the cell surface, which causes T cells (other immune cells) to attack these dendritic cells, which can result in significant immune system dysfunction or autoimmunity. In other words, this causes the immune system to attack itself.
Amplification : BioNTech, led by U. Sahin, says Comirnaty targets dendritic cells instead of muscle cells for mRNA uptake. This targeting increases mRNA potency by 1,000-fold.
BioNTech's official information : BioNTech's own material, including diagrams, illustrates the vaccine's effect on antigen-presenting cells such as dendritic cells, not muscle cells, which contradicts the narrative that the vaccine mainly remains at the injection site.
Public vs. scientific statements : There is a discrepancy between BioNTech's claim that the vaccine primarily targets dendritic cells and public statements suggesting that most of the mRNA remains in the muscles and that only harmless trace amounts go elsewhere.
Changes in antibody response : A shift from protective antibodies (IgG1/3) to tolerant antibodies (IgG4) has been observed after vaccination, especially after boosters, which may reduce the effectiveness of the immune response against SARS-CoV-2 by promoting tolerance rather than active immunity. In addition, there is a significant decrease in mucosal antibodies (IgA), which are essential for the initial defense against infectious diseases at entry points such as the nose, mouth and respiratory tract, suggesting a possible impairment of mucosal immunity.
Immune defense in children : A study from Hamburg found an “unusual” IgG4 response to the S1 subunit in children aged 5-11 years one year after Comirnaty vaccination. The long-term consequences for immunity are uncertain, raising concerns about the safety and efficacy of future mRNA vaccinations in this age group.
Increased susceptibility to disease : Data from various studies suggest that the more doses of Comirnaty vaccine one receives, the higher the risk of getting or experiencing breakthrough infections with SARS-CoV-2, suggesting a possible weakening or regulation of the immune system.
Neurological and vascular consequences : The S1 subunit of the spike protein produced by the vaccine has been linked to neuroinflammatory responses, potentially contributing to conditions such as chronic fatigue syndrome (ME/CFS) and increasing the risk of neurological symptoms. In addition, the effects of spike proteins on blood vessel cells can lead to damage to blood vessel walls, blood clots, and related complications.
Long-term effects and safety concerns : The persistence of the spike protein in the body, its ability to cross the blood-brain barrier, and the observed shift to tolerant antibodies (IgG4) raise questions about the long-term health of the immune system, especially in children, where the consequences are not yet fully understood. It is also acknowledged that further research is needed to assess the safety and efficacy of mRNA-LNP vaccines in light of these findings.
In summary, the genetic components and mechanisms of Comirnaty appear to have unintended effects on the immune system, even though they are designed to protect against Covid-19, potentially leading to a less effective or even counterproductive immune response to the virus, along with possible long-term health consequences that require further investigation.
Response from the Danish Minister of Health regarding the spike protein.
On March 13, 2024, I received a response to my second letter of concern to the Minister of Health, in which, among other things, the harmful effects of the spike protein were documented in 13 scientific studies(3).
The response from the Danish Medicines Agency can be seen below.
The precautionary principle.
There is a law that the precautionary principle regarding the safety of the population must prevail in cases of doubt.
Lex.dk states the following about the precautionary principle.
The precautionary principle concerns how legislators and authorities should deal with scientific uncertainty about possible significant risks of environmental or health damage from products or processes. This has three consequences. One is that the principle cannot be applied if the risks of an activity have been mapped. The second is that the principle can only be applied if there are scientific indications of risks. The principle cannot therefore justify intervention on the basis of fears that cannot be scientifically substantiated to a certain extent . The third consequence is that the principle can only be applied to risks of a certain significance.
Although the precautionary principle is enshrined in EU law and a recognized part of Danish law, the principle cannot in itself provide a basis for intervention by the authorities.
It is my personal impression, based on the regulatory investigations – or lack thereof – that I have become aware of through my questions to the Minister of Health and the Danish Medicines Agency, that this precautionary principle has not been complied with.
Sources:
1. The report by professor of human biology Ulrike Kämmerer.
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